The Myth of the Linear, No-Threshold Dose-Response Relationship for Carcinogens by George Parris

Author:George Parris [Parris, George]
Language: eng
Format: azw3
Published: 2013-04-27T04:00:00+00:00

Perhaps a more relevant example is provided by the case of “arsenic” (i.e., arsenic(III) oxide). Based on anecdotal evidence, arsenic (used in high oral doses to treat skin diseases) was reported to be a carcinogen in the late 1800s. The idea was attributed primarily to Sir Jonathan Hutchinson (1828 – 1913).274 Today, almost every paper (and there are thousands) that discusses the health effects of arsenic (in its many forms) begins with the statement that “arsenic is a known human carcinogen.” Arsenic is most infamous for its association with skin and bladder cancer; links to other sites have also been made through epidemiological studies (which need to be discussed separately).

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